ACHIEVEMENTS:研究業績 (2017~)


2024年

論文

Y. Takamatsu, T. Inoue, T. Nishio, K. Soma, Y. Kondo, T. Mishima, M. Okamura, T. Mishima, H. Takamura, M. Okamura, H. Maejima*

Potential effect of physical exercise on the downregulation of BDNF mRNA expression in rat hippocampus following intracerebral hemorrhage                                                     Neuroscience letters, 824, 137670, 2024    DOI:  https://doi.org/10.1016/j.neulet.2024.137670

T. Nishio, T. Inoue , Y. Takamatsu, T. Mishima , H. Takamura , K. Soma , Y. Kondo, M. Okamura , R. Ikegami , H. Maejima*

Epigenetic modification of histone acetylation in the sensorimotor cortex after intracerebral hemorrhage Biomedical research, 45(1): 1-11, 2024    DOI:  https://doi.org/10.2220/biomedres.45.1



2023年

論文

                                     

M. Okamura, T. Inoue, Y. Takamtsu, H. Maejima*                                      Pharmacological inhibition of histone deacetylases ameliorates cognitive impairment after intracerebral hemorrhage with epigenetic alteration in the hippocampus
Journal of Stroke and Cerebrovascular Diseases, 32 (9), 107275, 2023                               DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107275

T. Inoue, R. Ikegami, Y. Takamatsu, M. Fukuchi, S. Haga, M. Ozaki, H. Maejima*            

Temporal dynamics of brain BDNF expression following a single bout of exercise: a bioluminescence imaging study 
Neuroscience Letters, 799, 137120, 2023    DOI: https://doi.org/10.1016/j.neulet.2023.137120 

H. Maejima*, M. Okamura, T. Inoue, Y. Takamatsu, T. Nishio, Y. Liu                                 Epigenetic modifications in the motor cortex caused by exercise or pharmacological inhibition of histone deacetylases (HDACs) after intracerebral hemorrhage (ICH) 
Brain Reseach, 1806, 148286, 2023    DOI: https://doi.org/10.1016/j.brainres.2023.148286 

学会発表

Maejima H., Xing Li., Sakaguchi M., Y., Sugiyama T. Effects of aging and exercise on the expression of a receptor of coronavirus SARS-CoV-2 in the brain. The 45st Annual Meeting of the Japan Neurosciece Society (Neuro2023). Sendai, 2023.8.2.

Liu. Y., Chen K., Takamatsu Y., Oka Y., Maejima H. Effects of skilled reaching training and pharmacological inhibition of histone deacetylases on motor recovery after intracerebral hemorrhage. The 45st Annual Meeting of the Japan Neurosciece Society (Neuro2023). Sendai, 2023.8.2.

Sugiyama T., Takamatsu Y., Nishio T., Liu Y., Haga S., Ozaki M., Fukuchi M., Maejima H. Effects of exercise and inhibition of histone deacetylase on the expression of brain derived neurotrophic factor: A bioluminescence imaging study. The 45st Annual Meeting of the Japan Neurosciece Society (Neuro2023). Sendai, 2023.8.2.


2022年

論文

T. Inoue, Y. Takamatsu, T. Nishio, K. Soma, M. Okamura, H. Tohyama, H. Maejima*
Combined treatment with exercise and α5GABAAR inhibitor promotes motor function recovery after intracerebral hemorrhage
Neuroscience Letters, 766, 136344, 2022 DOI: 10.1016/j.neulet.2021.136344

学会発表

Maejima H., Ikagami R., Inoue T., Yakamatsu Y., Fukuchi M., Haga S., Ozaki M, In vivo imaging of exercise-induced BDNF expression in the brain using Bdnf-Luc Tg mice, The Society for Neuroscience 51th Annual Meeting (Neuroscience 2022), San Diego, 11/11, 2022


高松 泰行, 相馬 希帆, 西尾 太一, 高村 巴菜, 三島 大雅, 井上 貴博, 前島 洋, 脳出血およびその後の運動が海馬における脳由来神経栄養因子発現に与える影響, 第27回 日本基礎理学療法学会学術大会, O-1-3-3, 大阪, 10/1-2, 2022

西尾 太一, 井上 貴博, 三島 大雅, 相馬 希帆, 高村 巴菜, 高松 泰行, 前島 洋, 脳内出血後の運動は損傷側大脳皮質におけるヒストンアセチル化を増強する, 第27回 日本基礎理学療法学会学術大会, P-3-1-5, 大阪, 10/1-2, 2022

前島 洋, 運動による脳におけるエピジェネティクス調整機構と神経栄養因子発現の修飾(シンポジウム: 運動が多臓器に誘導する多彩なエピジェネティクス調整機構), 第77回日本体力医学会大会, 宇都宮市, 9/23, 2022. 

Maejima H., Okamura M., Inoue T., Takamatsu Y, Different epigenetic modifications between ipsilateral and contralateral motor cortex caused by exercise and pharmacological inhibition of histone deacetylases after intracerebral hemorrhage, The 44st Annual Meeting of the Japan Neurosciece Society (Neuro2022), Okinawa, 7/1, 2022 


2021年

論文

S. Otsuka, H. Sakakima, A. Tani, K. Nakanishi, S. Takada, K. Norimatsu, H. Maejima, I. Maruyama
Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats
Brain Structure and Function, 226(7), pp.2169-2180, 2021 DOI: 10.1007/s00429-021-02317-5

T. Inoue, Y. Takamatsu, M. Okamura, H. Maejima*
Ipsilateral BDNF mRNA expression in the motor cortex positively correlates with motor function of the affected forelimb after intracerebral hemorrhage
Brain Research, 1767, 147536, 2021 DOI: 10.1016/j.brainres.2021.147536

T. Inoue, Y. Takamatsu, M. Okamura, H. Mani, N. Hasegawa, H. Maejima*
Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex
Biomedical Research, 42(3), pp.103-108, 2021 DOI: 10.2220/biomedres.42.103

Y. Takamatsu*, T. Inoue, M. Okamura, R. Ikegami, H.Maejima
In vivo local transcranial static magnetic field stimulation alters motor behavior in normal rats
Neuroscience Letters, 749, 135749, 2021 DOI: 10.1016/j.neulet.2021.135864

Y. Takamatsu, S. Koganemaru, T. Watanabe, S. Shibata, Y. Yukawa, M. Minakuchi, R. Shimomura, T. Mima
Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human
Scientific Reports, 11, 5370, 2021 DOI: 10.1038/s41598-021-84823-4

M. Kitahara, T. Inoue, H. Mani, Y. Takamatsu, R. Ikegami, H. Tohyama, H. Maejima*
Exercise and pharmacological inhibition of histone deacetylase improves cognitive function accompanied by an increase of gene expressions crucial for neuronal plasticity in the hippocampus
Neuroscience Letters, 749, 135749, 2021 DOI: 10.1016/j.neulet.2021.135749

H. Maejima*, M. Kitahara, Y. Takamatsu, H. Mani, T. Inoue
Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and
gene expressions crucial for neuronal plasticity in the motor cortex

Brain Research, 1751, 147191, 2021 DOI: 10.1016/j.brainres.2020.147191

学会発表

H. Maejima, M. Kitahara, Y. Takamatsu, H. Mani, T. Inoue, Pharmacological inhibition of histone deacetylases (HDACs) presents an enriched neuronal platform in the brain for neurorehabilitation, Neuroscience 2021 (The Society for Neuroscience 50th Annual Meeting), P309.01, Web, Nov 8-11, 2021

T. Inoue, Y. Takamatsu, T. Nishio, K. Soma, M. Okamura, H. Tohyama, H. Maejima, Treadmill exercise concurrent with pharmacological inhibition of alpha5-GABAA receptor improves motor function and enhances spinal cord plasticity after intracerebral hemorrhage in rats, Neuroscience 2021 (The Society for Neuroscience 50th Annual Meeting), P336.03, Web, Nov 8-11/13-16, 2021 JNS-SfN Exchange Travel Award 受賞

西尾 太一, 三島 大雅, 相馬 希帆, 近藤 裕輝, 高村 巴菜, 井上 貴博, 岡村 未里, 高松 泰行, 前島 洋, 脳出血モデルラットに対するトレッドミル運動は前肢運動協調性を改善する, 第26回 日本基礎理学療法学会学術大会, 2G2-03, Web, 10/24, 2021

井上 貴博, 高松 泰行, 西尾 太一, 相馬 希帆, 岡村 未里, 遠山 晴一, 前島 洋, 運動介入とα5GABA受容体阻害薬の投与が脳出血モデルラットの機能回復に与える影響, 第26回 日本基礎理学療法学会学術大会, 2G2-02, Web, 10/24, 2021
優秀賞 受賞

井上 貴博, 高松 泰行, 西尾 太一, 前島 洋, 運動とα5GABA受容体阻害薬の併用は脳出血後の脊髄TrkB遺伝子発現を促進する, 第19回 コ・メディカル形態機能学会学術集会, 口演Ⅱ-5, Web, 9/11, 2021 学会優秀賞 受賞

H. Maejima, M. Okamura, T. Inoue, Y. Takamatsu, Epigenetic modifications in the motor cortex caused by exercise plus pharmacological inhibition of histone deacetylases (HDACs) after intracerebral hemorrhage, The 44th Annual Meeting of the Japan Neuroscience Society, 4P-356, Kobe/Web, July 28-31 2021

T. Inoue, H. Takamura, T. Nishio, K. Soma, Y. Takamatsu, H. Maejima, Temporal changes in GFAP gene expression in the motor cortex after intracerebral hemorrhage, The 44th Annual Meeting of the Japan Neuroscience Society, 4P-355, July 28-31, 2021

Y. Takamatsu, T. Inoue, M. Okamura, R. Ikegami, H. Maejima, In vivo transcranial static magnetic field stimulation over the primary motor cortex causes inhibitory changes of motor function in normal rats, The 98th Annual Meeting of the Physiological Society of Japan, a90016, Mar 28-30, 2021

R. Ikegami, M. Kitahara, T. Inoue, H. Mani, Y. Takamatsu, H. Tohyama, H. Maejima, Exercise and pharmacological inhibition of histone deacetylase improves cognitive function in normal mice, The 98th Annual Meeting of the Physiological Society of Japan, a90105, Mar 28-30, 2021

T. Inoue, Y. Takamatsu, M. Okamura, H. Maejima, BDNF mRNA expression level in the ipsilateral motor cortex correlates with motor impairment of paralyzed forelimb after intracerebral hemorrhage in rats, SfN Global Connectome 2021, P140.01, Jan 11, 2021


2020年

論文

M. Okamura, T. Inoue, Y. Takamatsu, H. Maejima*
Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke
Journal of Stroke and Cerebrovascular Diseases, 29(12), 105316, 2020
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105316

T. Inoue, M. Okamura, M. Kitahara, Y. Takamatsu, H. Sakakima, H. Maejima*
Exercise plus pharmacological neuromodulation of synaptic inhibition enhance motor function recovery after ischemic stroke
Neuroscience, 430, pp.12-24, 2020 DOI: 10.1016/j.neuroscience.2020.01.012


学会発表

岡村 未里, 井上 貴博, 高松 泰行, 萬井 太規, 前島 洋, 脳出血モデルラットに対するトレッドミル走行が認知機能に与える影響, 第25回日本基礎理学療法学会学術大会, 1G2-02, 12/12-18, 2020

高松 泰行 , 西川 淳, 健常ラットに対する in vivo 局所経頭蓋的静磁場刺激の効果および作用機序の検証, 第6回 北海道大学部局横断シンポジウム, K-27, 10/19, 2020

井上 貴博, 高松 泰行, 岡村 未里, 前島 洋, 脳出血後の運動機能障害と大脳皮質におけるBDNF遺伝子発現の関係, 第6回 北海道大学部局横断シンポジウム, p_b1_04f_05, 10/19, 2020

T. Inoue, Y. Takamatsu, M. Okamura, H. Mani, N. Hasegawa, H. Maejima, Pharmacological neuromodulation reducing tonic inhibition of GABAA receptors upregulates neuronal activity in the motor cortex in rats, 11th World Congress for Neurorehabilitation (WCNR 2020), P0367, Oct 7-11, 2020

T. Inoue, Y. Takamatsu, M. Okamura, H. Mani, H. Maejima, Time course of motor impairments after intracerebral hemorrhage with internal capsule injury in rats, The 43rd Annual Meeting of the Japan Neuroscience Society, LBA-048, July 29, 2020


2019年

論文

H. Maejima*, T. Inoue, Y. Takamatsu
Therapeutic exercise accompanied by neuronal modulation to enhance neurotrophic factors in the brain with central nervous system disorders
Physical Therapy Research, 22(1), pp.38-43, 2019 DOI: 10.1298/ptr.R0004

Takamatsu Y*, Matsuda N, Aiba I
The combination of short-step and wide-based gait is a gait characteristic in progressive supranuclear palsy: a retrospective, cross-sectional study
European Geriatric Medicine, 10:809-815, 2019 DOI: 10.1007/s41999-019-00211-2

X. Li, T. Inoue, M. Hayashi, H. Maejima*
Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8
Neuroscience Letters, 706, pp.176-181, 2019 DOI: 10.1016/j.neulet.2019.05.031

T. Inoue*, K. Taneda
Transcranial Direct Current Stimulation Modulates GABA Levels Beyond the Stimulated Region: Perspectives for Stroke Rehabilitation
The Journal of Neuroscience, 39(10), pp.1768-1770, 2019 DOI: 10.1523/JNEUROSCI.2524-18.2018


学会発表

北原 美佳, 井上 貴博, 萬井 太規, 高松 泰行, 前島 洋, エピジェネティクス制御を伴う有酸素運動が海馬における脳由来神経栄養因子の発現に与える影響, 第24回日本基礎理学療法学会学術大会, 2O9-05, 新潟, 12/1, 2019

H. Maejima, M. Hayashi, T. Inoue, M. Kitahara, Voluntary exercise combined with repetitive inhibition of GABAergic synapses modulates the expression of BDNF in the motor cortex, Neuroscience 2019 (The Society for Neuroscience 49th Annual Meeting), 368.03/B24, Chicago, IL, Oct 19-23, 2019

T. Inoue, M. Kitahara, M. Okamura, Y. Takamatsu, H. Maejima, Combination of exercise and pharmacological neuromodulation targeting GABAA receptors promotes motor recovery and BDNF protein expression in the M1 after focal brain ischemia in rats, Neuroscience 2019 (The Society for Neuroscience 49th Annual Meeting), 368.01/B22, Chicago, IL, Oct 21, 2019

T. Inoue, M. Okamura, M. Kitahara, Y. Takamatsu, H. Maejima, Treadmill exercise beneficially contributes to gene expressions relating to synaptic and axonal plasticity in the motor cortex after ischemic stroke in rats, The 1st International Sport Neuroscience Conference, P31, Tsukuba, Sep 18, 2019 Travel Award 受賞

井上 貴博, 脳卒中リハビリテーションにおけるGABA受容体を標的とした薬理的ニューロモジュレーション, 第4回 基礎理学療法学 夏の学校, 若手研究者講演 O-1-5, 鹿児島, 8/24, 2019

H. Maejima, M. Kitahara, T. Inoue, Y. Takamatsu, Exercise combined with repetitive inhibition of histone deacetylases modulates the expression of neurotrophin in the cerebral cortex, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society), PA-L-523, Niigata, July 25, 2019

Y. Takamatsu, S. Koganemaru, T. Watanabe, Y. Yukawa, M. Minakuchi, R. Shimomura, T. Mima, Transcranial static magnetic stimulation over the unilateral primary motor cortex induces the different changing of cortical excitability on both hemispheres, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society), PB-238, Niigata, July 27, 2019

A. Sinha, Y. Takamatsu, T. Akita, T. Mima, A. Fukuda, Static magnetic fields reduce excitability of pyramidal neurons by enhancing membrane Cl− conductance in the mouse motor cortex. NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society) , PB-092, Niigata, July 27, 2019

T. Inoue, Y. Takamatsu, H. Maejima, The interactive effects of GABAA receptor antagonist and exercise on the recovery of motor function and BDNF expression in the ipsilesional M1 after ischemic stroke in rats, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society), PA-365, Niigata, July 25, 2019

M. Okamura, T. Inoue, A. Kako, Y. Takamatsu, H. Maejima, The effects of low-intensity exercise on the gene expressions relating to synaptic plasticity in the hippocampus following ischemic stroke in rats, NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society), PA-359, Niigata, July 25, 2019

H. Maejima, X Li, T. Inoue, M. Hayashi, Exercise habit enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic changes in senescence-accelerated mice prone 8, FENS Regional Meeting 2019, P359, Belgrade, July 13, 2019


2018年

論文

H. Maejima*, S. Ninuma, A. Okuda, T. Inoue, M. Hayashi
Exercise and low-level GABAA receptor inhibition modulate locomotor activity and the expression of BDNF accompanied by changes in epigenetic regulation in the hippocampus
Neuroscience Letters, 685, pp.18-23, 2018 DOI: 10.1016/j.neulet.2018.07.009

H. Maejima*, N. Kanemura, T. Kokubun, K. Murata, K. Takayanagi
Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice
Neuroscience Letters, 665, pp.67-73, 2018 DOI: 10.1016/j.neulet.2017.11.023

T. Inoue, S. Ninuma, M. Hayashi, A. Okuda, T. Asaka, H. Maejima* 
Effects of long-term exercise and low-level inhibition of GABAergic synapses on motor control and the expression of BDNF in the motor related cortex
Neurological Research, 40(1) pp.18-25, 2018 DOI: 10.1080/01616412.2017.1382801


学会発表

井上 貴博, 林 聖隆, 李 想, 北原 美佳, 前島 洋, GABA受容体阻害下の運動療法が脳梗塞モデルラットの機能回復に与える影響, 第23回日本基礎理学療法学会学術大会, O9-1, 京都, 12/16, 2018

井上 貴博, 薬理的中枢性コンディショニングを伴う運動療法の検討ー神経栄養因子の発現からー, 第3回 基礎理学療法学 夏の学校, P-06, 名古屋, 8/25, 2018 Most Impressive Presenter賞 受賞

Y. Takamatsu, Sinha S Adya, T. Akita, A. Fukuda, T. Mima, Static magnetic fields can temporarily alter the membrane excitability of mouse pyramidal neurons, The 41st Annual Meeting of the Japan Neuroscience Society, 1P-137, Kobe, July 26, 2018

T. Inoue, S. Ninuma, M. Hayashi, A. Okuda, T. Asaka, H. Maejima, Low-level inhibition of GABAA receptor and motor exercise modulate BDNF expression in the motor related cortex, The 41st Annual Meeting of the Japan Neuroscience Society, 3P-001, Kobe, July 28, 2018

X. Li, T. Inoue, M. Hayashi, M. Kitahara, H. Maejima, The effect of aging and long-term exercise on the expression of BDNF in the hippocampus of senescent accelerated mice accompanied by epigenetic alternations, The 41st Annual Meeting of the Japan Neuroscience Society, 3P-LBA15, Kobe, July 28, 2018

H. Maejima, M. Kitahara, M. Hayashi, T. Inoue, X. Li, Site-specific modulation of BDNF expression in the brain following chronic GABAA receptor inhibition, 11th FENS Forum of Neuroscience, B030, Berlin, Germany, July 8, 2018


2017年

論文

Hasegawa N., Takeda K., Sakuma M., Mani H., Maejima H., Asaka T.
Learning effects of dynamic postural control by auditory biofeedback versus visual biofeedback training
Gait & Posture 58: 188-193, 2017 DOI: 10.1016/j.gaitpost.2017.08.001

Takeda K., Mani H., Hasegawa N., Sato Y., Tanaka S., Maejima H., Asaka T.
Adaptation effects in static postural control by providing simultaneous visual feedback of center of pressure and center of gravity
J Physiological Anthropology 36: 31, 2017 DOI: 10.1186/s40101-017-0147-5

Ibuki A., Mani H., Takeda K., Hasegawa N., Yamamoto K., Maejima H., Asaka T.
Characteristic relationship between the center of pressure and the center of mass during quiet standing in female ballet dancers
International Physical Medicine & Rehabilitation Journal 1(2), 2017 DOI: 10.15406/ipmrj.2017.01.00009

Takahashi K, Maejima H*, Ikuta G, Mani H, Asaka T
Exercise combined with low-level GABAA receptor inhibition up-regulates the expression of neurotrophins in the motor cortex
Neuroscience Letters 636, pp.101-107, 2017 DOI: 10.1016/j.neulet.2016.10.052

Okimoto A, Toriyama M, Deie M, Maejima H*
Decline of Hip Joint Movement Relates to Overestimation of Maximum Forward Reach in Elderly Persons
Journal of Motor Behavior 49(6), pp.611-618, 2017 DOI: 10.1080/00222895.2016.1250714


学会発表

H. Maejima, S. Ninuma, A. Okuda, T. Inoue, M. Hayashi, Exercise combined with low-level GABAA receptor inhibition modulates the expression of BDNF in the hippocampus accompanied by changes in epigenetic regulation, The Society for Neuroscience 47th Annual Meeting (Neuroscience 2017), 373.14/D10, Washington, DC, Nov 13, 2017

T. Inoue, S. Ninuma, M. Hayashi, A. Okuda, T. Asaka, H. Maejima, The effects of long-term exercise combined with low-level GABAergic synapses on motor control and the expression of BDNF in the motor cortex, The 3rd FHS International Conference, 1-31, Sapporo, July 07, 2017

Takahashi K., Maejima H., Ikuta G., Mani H., Asaka T. Exercise combined with low-level GABAA receptor inhibition up-regulates the expression of neurotrophins in the motor cortex. Experimental Biology 2017, Chicago, IL. April 24, 2017. 

 Maejima H., Kanemura N., Kokubun T., Murata K., Takayanagi K. Effects of aging and treadmill exercise on cognitive function and the expression of BDNF in the hippocampus. Experimental Biology 2017, Chicago, IL. April 25, 2017. 

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